FACTORS AFFECTING THE LEVEL OF GLYCATED HEMOGLOBIN IN HOSPITALIZED TYPE 2 DIABETES MELLITUS PATIENTS

Abstract

Today type 2 diabetes mellitus is a socially significant disease with a high growth rate in the number of patients and the risk micro- and macrovascular complications. Modern diabetology considers the level of glycated hemoglobin to be the most important tool for diagnosing type 2 diabetes mellitus. The efficacy of therapy is assessed by the target values of this very indicator. The aim of the study was to analyze the correlation between the level of glycated hemoglobin in type 2 diabetes mellitus patients, hospitalized to a specialized endocrinology department, and a number of clinical and epidemiological characteristics that are mandatory for describing the patient’s status. Materials and Methods. The authors conducted a retrospective analysis of case histories of type 2 diabetes mellitus patients hospitalized to the endocrinology department of Ulyanovsk Regional Clinical Hospital in 2020. Continuous sampling method was used. Results on the correlation between the diagnosis and the glycated hemoglobin value were obtained. Statistica 13 (StatSoft) was used for data processing. The level of glycated hemoglobin was assessed once, when the patient was hospitalized, by high performance liquid chromatography on a Bio Rad analyzer. Results. When conducting multivariate regression analysis, negative correlations close to linear were found in the pairs “glycated hemoglobin - duration of type 2 diabetes mellitus anamnesis” and “glycated hemoglobin - number of concomitant diagnoses not associated with type 2 diabetes mellitus”. Such patterns may be explained by the fact that a longer duration of the disease and a wider range of comorbid pathologies increase patients’ adherence to treatment and physician’s recommendations. Conclusion. The work conducted allows us to clarify the mechanisms of influence on the patient's compliance in type 2 diabetes mellitus treatment.