1. Division of Pulmonary and Critical Care Medicine, Pennsylvania State University College of Medicine, Hershey, PA, USA;
2. Department of Physiology, Pennsylvania State University College of Medicine, Hershey, PA, USA;
3. Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, PA, USA;
4. Department of Medicine, Lewis Katz School of Medicine of Temple University, Philadelphia, PA, USA;
5. Center of Translational Medicine, Lewis Katz School of Medicine of Temple University, Philadelphia, PA, USA;
6. Institut Cochin, INSERM U1016-CNRS UMR8104, Université Paris Descartes, Paris, France