Population pharmacokinetic model-based dosing proposal for ampicillin prophylaxis in cardiac surgery patients with cardiopulmonary bypass

Author:

Urbánek Karel1,Šantavý Petr2,Zuščich Ondřej2,Kubíčková Vendula1,Michaličková Danica3,Slanař Ondřej3,Šíma Martin3ORCID

Affiliation:

1. Department of Pharmacology, Faculty of Medicine and Dentistry, Palacký University and University Hospital, Olomouc, Czech Republic

2. Department of Cardiac Surgery, Faculty of Medicine and Dentistry, Palacký University and University Hospital, Olomouc, Czech Republic

3. Department of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

Funder

Agentura Pro Zdravotnický Výzkum České Republiky

Publisher

Informa UK Limited

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology,Oncology

Reference19 articles.

1. Ampicillin-sulbactam: an update on the use of parenteral and oral forms in bacterial infections

2. Grayson ML, Cosgrove S, Crowe SM. Kucers’ the use of antibiotics: a clinical review of antibacterial, antifungal, antiparasitic, and antiviral drugs. 7th ed. Boca Raton (FL): CRC Press; 2018.

3. State Institute for Drug Control of Czech Republic. Unasyn – Summary of Product Characteristics. [updated Dec 11 2020; cited May 25 2022]. Available from: https://www.sukl.cz/modules/medication/detail.php?code=0016600&tab=texts.

4. The Society of Thoracic Surgeons Practice Guideline Series: Antibiotic Prophylaxis in Cardiac Surgery, Part II: Antibiotic Choice⁎⁎For the full text of the STS Guideline on Antibiotic Prophylaxis in Cardiac Surgery, as well as other titles in the STS Practice Guideline Series, visit http://www.sts.org/sections/aboutthesociety/practiceguidelines/ at the official STS website (www.sts.org).

5. Epidemiology and prevention of surgical site infections after cardiac surgery

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