Blood-based traumatic brain injury biomarkers – Clinical utilities and regulatory pathways in the United States, Europe and Canada

Author:

Wang Kevin K.12ORCID,Munoz Pareja Jennifer C.3,Mondello Stefania4,Diaz-Arrastia Ramon5,Wellington Cheryl6,Kenney Kimbra7,Puccio Ava M.8,Hutchison Jamie9,McKinnon Nicole9,Okonkwo David O.10,Yang Zhihui12,Kobeissy Firas12,Tyndall J. Adrian1,Büki András,Czeiter Endre11,Pareja Zabala Maria C.12,Gandham Nithya1,Berman Rebecca13,

Affiliation:

1. Program for Neurotrauma, Neuroprotoemics & Biomarker Research, Department of Emergency Medicine, University of Florida College of Medicine, Gainesville, Florida, USA

2. Brain Rehabilitation Research Center (BRRC), Malcom Randall Veterans Affairs Medical Center, Gainesville, Florida, USA

3. Department of Pediatric Critical Care, University of Miami Miller School of Medicine, Miami, Florida, USA

4. Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy

5. Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

6. Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Canada

7. Department of Neurology, Uniformed Service University, Bethesda, Maryland, USA

8. Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

9. The Hospital for Sick Children, Department of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada

10. Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

11. Department of Neurosurgery, Pecs University, Pecs, Hungary

12. Fundación Universitaria Sanitas, Bogota, Colombia

13. National Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, MD, USA

Funder

U.S. Army Medical Research and Material Command

U.S. Department of Veterans Affairs Long-term Impact of Military-related Brain Injury Consortium/Chronic Effects of Neurotrauma Consortium

The U.S. Army Medical Research Acquisition Activity

Publisher

Informa UK Limited

Subject

Genetics,Molecular Biology,Molecular Medicine,Pathology and Forensic Medicine

Reference198 articles.

1. The Epidemiology and Impact of Traumatic Brain Injury

2. Gerberding JL, Binder S. National center for injury prevention and control centers for disease, control. Report to Congress on Mild Traumatic Brain Injury in the United States: Steps to Prevent a Serious Public Health Problem. Atlanta, GA 1–56; 2003.

3. The Traumatic Brain Injury Endpoints Development (TED) Initiative: Progress on a Public-Private Regulatory Collaboration To Accelerate Diagnosis and Treatment of Traumatic Brain Injury

4. Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research

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