Microcin MccI47 selectively inhibits enteric bacteria and reduces carbapenem-resistant Klebsiella pneumoniae colonization in vivo when administered via an engineered live biotherapeutic

Author:

Mortzfeld Benedikt M.12ORCID,Palmer Jacob D.34ORCID,Bhattarai Shakti K.12ORCID,Dupre Haley L.5,Mercado-Lubio Regino1ORCID,Silby Mark W.6ORCID,Bang Corinna7ORCID,McCormick Beth A.12ORCID,Bucci Vanni128ORCID

Affiliation:

1. Department of Microbiology and Physiological Systems, Universty of Massachusetts Chan Medical School, Worcester, MA, USA

2. Program in Microbiome Dynamics, Universty of Massachusetts Chan Medical School, Worcester, MA, USA

3. Department of Zoology, University of Oxford, Oxford, UK

4. Department of Biochemistry, University of Oxford, Oxford, UK

5. Department of Bioengineering, University of Massachusetts Dartmouth, North Dartmouth, MA, USA

6. Department of Biology, University of Massachusetts Dartmouth, Dartmouth, MA, USA

7. Institute of Clinical Molecular Biology, Christian-Albrechts-Universität Zu Kiel, Kiel, Germany

8. Program in Systems Biology, Universty of Massachusetts Chan Medical School, Worcester, MA, USA

Funder

UMass Office of the President

Deutsche Forschungsgemeinschaft

Department of Defense Congressionally Directed Medical Research Programs

Publisher

Informa UK Limited

Subject

Infectious Diseases,Microbiology (medical),Gastroenterology,Microbiology

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