Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies

Author:

Akwa Yvette1ORCID,Di Malta Chiara23ORCID,Zallo Fátima4,Gondard Elise5,Lunati Adele6,Diaz-de-Grenu Lara Z.47,Zampelli Angela2,Boiret Anne16,Santamaria Sara8,Martinez-Preciado Maialen4,Cortese Katia8ORCID,Kordower Jeffrey H.910ORCID,Matute Carlos4ORCID,Lozano Andres M.511,Capetillo-Zarate Estibaliz412ORCID,Vaccari Thomas13ORCID,Settembre Carmine214ORCID,Baulieu Etienne E.16ORCID,Tampellini Davide16ORCID

Affiliation:

1. Department of Diseases and Hormones of the Nervous System, U1195 INSERM - Université Paris-Saclay, Le Kremlin-Bicêtre, France

2. Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy

3. Department. of Translational Medicine, Medical Genetics, Federico II University, Naples, Italy

4. Achucarro Basque Center for Neuroscience, Departamento de Neurociencias, Universidad del País Vasco (UPV/EHU) and Centro de Investigación en Red de Enfermedades, Neurodegenerativas (CIBERNED), Leioa, Spain

5. Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada

6. Institut Professeur Baulieu, Le Kremlin-Bicêtre, France

7. TECNALIA, Basque Research and Technology Alliance (BRTA), Derio, Spain

8. Cellular Electron Microscopy Lab, DIMES, Department of Experimental Medicine, University of Genoa, Genova, Italy

9. Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA

10. College of Liberal Arts and Sciences, Arizona State University, Tempe, AZ, USA

11. Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada

12. IKERBASQUE, Basque Foundation for Science, Bilbao, Spain

13. Department of Biosciences, University of Milan, Milan, Italy

14. Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy

Publisher

Informa UK Limited

Subject

Cell Biology,Molecular Biology

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