TIGAR exacerbates obesity by triggering LRRK2-mediated defects in macroautophagy and chaperone-mediated autophagy in adipocytes

Author:

Zhang Tian123,Linghu Ke-Gang1,Tan Jia2,Wang Mingming4,Chen Diao2,Shen Yan2,Wu Junchao4,Shi Mingjun235,Zhou Yuxia23,Tang Lei6,Liu Lirong1,Qin Zheng-Hong47,Guo Bing235

Affiliation:

1. Guizhou Institute of Precision Medicine, Affiliated Hospital of Guizhou Medical University, Guizhou Medical University, Guiyang, Guizhou, China

2. Department of Pathophysiology, Guizhou Medical University, Guiyang, Guizhou, China

3. Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang, Guizhou, China

4. Department of Pharmacology, Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Neuropsychiatric Diseases, College of Pharmaceutical Science, Soochow University, Suzhou, Jiangsu, China

5. Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry, Guizhou Medical University, Guiyang, Guizhou, China

6. Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, Guizhou, China

7. Institute of Health Technology, Global Institute of Software Technology, Suzhou, Jiangsu, China

Funder

National Natural Science Foundation

Excellent Young Talents Plan of Guizhou Medical University

Guizhou Provincial Innovation and Entrepreneurship Projects for Overseas Talents

Publisher

Informa UK Limited

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