A surge in endogenous spermidine is essential for rapamycin-induced autophagy and longevity

Author:

Hofer Sebastian J.123ORCID,Daskalaki Ioanna45ORCID,Abdellatif Mahmoud26ORCID,Stelzl Ulrich237ORCID,Sedej Simon268ORCID,Tavernarakis Nektarios49ORCID,Kroemer Guido101112ORCID,Madeo Frank123ORCID

Affiliation:

1. Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria

2. BioTechMed-Graz, Graz, Austria

3. Field of Excellence BioHealth, University of Graz, Graz, Austria

4. Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology – Hellas, Heraklion, Greece

5. Department of Biology, School of Sciences and Engineering, University of Crete, Heraklion, Greece

6. Division of Cardiology, Medical University of Graz, Graz, Austria

7. Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz, Graz, Austria

8. Institute of Physiology, Faculty of Medicine, University of Maribor, Maribor, Slovenia

9. Division of Basic Sciences, School of Medicine, University of Crete, Heraklion, Greece

10. Centre de Recherche des Cordeliers, Équipe Labellisée par la Ligue Contre le Cancer, Université de Paris Cité, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France

11. Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France

12. Institut du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges Pompidou, AP-HP, Paris, France

Funder

Austrian Science Fund

Styrian Government

Medical University of Graz

Publisher

Informa UK Limited

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