Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3

Author:

Liu Zheng-Zhao12345,Hong Chun-Gu25,Hu Wen-Bao56ORCID,Chen Meng-Lu23,Duan Ran23,Li Hong-Ming12,Yue Tao12,Cao Jia2,Wang Zhen-Xing2,Chen Chun-Yuan12,Hu Xiong-Ke2,Wu Ben2,Liu Hao-Ming2,Tan Yi-Juan2,Liu Jiang-Hua12,Luo Zhong-Wei12,Zhang Yan12,Rao Shan-Shan27,Luo Ming-Jie27,Yin Hao12,Wang Yi-Yi12,Xia Kun12,Xu Lang2,Tang Si-Yuan7,Hu Rong-Gui89,Xie Hui12348

Affiliation:

1. Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China

2. Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China

3. Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, China

4. Hunan Key Laboratory of Organ Injury, Aging and Regenerative Medicine, Xiangya Hospital, Changsha, Hunan 410008, China

5. Shenzhen Second People’s Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China

6. Hunan Key Laboratory of Bone Joint Degeneration and Injury, Xiangya Hospital, Changsha, Hunan 410008, China

7. Xiangya Nursing School, Central South University, Changsha, Hunan, China

8. State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network; Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Shanghai 200031, China

9. Institue of Molecular Precision Medicine, Xiangya Hospital, Changsha, Hunan 410008, China

Funder

China Postdoctoral Science Foundation

Fundamental Research Funds for Central Universities of the Central South University

Innovation-Driven Project of Central South University

National Natural Science Foundation of China

Shenzhen Foundation of Science and Technology

Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences

Science and Technology Plan Project of Hunan Province

Guangdong Basic and Applied Basic Research Foundation

Publisher

Informa UK Limited

Subject

Cell Biology,Molecular Biology

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