1. Center for Systems Biology, Center for Assessment Technology & Continuous Health (CATCH), Massachusetts General Hospital, Boston, MA, USA;
2. Faculty of Medicine, Harvard Medical School, Boston, MA, USA;
3. Merck & Co., Inc, Kenilworth, NJ, USA;
4. Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA;
5. Medidata Solutions, New York, NY, USA