The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation-Reference-Cited by-同舟云学术

The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation

Published:2017-05-04 Issue:4 Volume:39 Page:199-210
ISSN:0892-3973
Container-title:Immunopharmacology and Immunotoxicology
language:en
Short-container-title:Immunopharmacology and Immunotoxicology

Author:

Blom Kristin¹,Senkowski Wojciech¹,Jarvius Malin¹,Berglund Malin¹,Rubin Jenny¹,Lenhammar Lena¹,Parrow Vendela¹,Andersson Claes¹,Loskog Angelica²,Fryknäs Mårten¹,Nygren Peter²,Larsson Rolf¹^ORCID

Affiliation:

1. Department of Medical Sciences, Division of Cancer Pharmacology and Computational Medicine, Uppsala University, Uppsala, Sweden;

2. Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden

Funder

Swedish Cancer Society

Lions Cancer Research Fund

Swedish Cancer Foundation

Publisher

Informa UK Limited

Subject

Pharmacology,Toxicology,General Medicine,Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/08923973.2017.1320671

Reference46 articles.

1. Repurposing drugs in oncology (ReDO)—Cimetidine as an anti-cancer agent

2. Mebendazole Induces Apoptosis via Bcl-2 Inactivation in Chemoresistant Melanoma Cells

3. Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme

4. Mebendazole inhibits growth of human adrenocortical carcinoma cell lines implanted in nude mice

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