CF 2 H: a fascinating group for application in drug development enabling modulation of many molecular properties
Author:
Affiliation:
1. The Department of Organic Chemistry, Israel Institute for Biological Research, Ness-Ziona, 74100, Israel
Publisher
Informa UK Limited
Link
https://www.tandfonline.com/doi/pdf/10.1080/17568919.2024.2359358
Reference20 articles.
1. Late-stage difluoromethylation: concepts, developments and perspective
2. Difluoromethyl Bioisostere: Examining the “Lipophilic Hydrogen Bond Donor” Concept
3. Facts, Patterns, and Principles in Drug Discovery: Appraising the Rule of 5 with Measured Physicochemical Data
4. CF2H, a Hydrogen Bond Donor
5. Utilizing the CF2H moiety as a H-bond-donating group in drug discovery
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