Design, synthesis, and biological evaluation of novel carbazole derivatives as potent DNMT1 inhibitors with reasonable PK properties

Author:

Li Ennian1,Wang Kai1,Zhang Bei1,Guo Siqi23,Xiao Senhao2,Pan Qi1,Wang Xiaowan1,Chen Weiying14,Wu Yunshan14,Xu Hesong25,Kong Xiangqian6,Luo Cheng25,Chen Shijie25,Liu Bo1478

Affiliation:

1. Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China

2. State Key Laboratory of Drug Research, The Center for Chemical Biology, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

3. School of Pharmacy, Nanchang University, Nanchang, China

4. Guangzhou Key Laboratory of Chirality Research on Active Components of Traditional Chinese Medicine, Guangzhou, China

5. School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China

6. Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

7. State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangzhou, China

8. Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, Guangzhou University of Chinese Medicine, Guangzhou, China

Funder

Key-Area Research and Development Program of Guangdong Province

National Natural Science Foundation of China

The special foundation of Guangzhou Key Laboratory

Science and Technology Planning Project of Guangdong Province

Special Funds for Inheriting and Developing the Traditional Chinese Medicine from TCM Bureau of Guangdong Province

Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine

Guangzhou University of Chinese Medicine

Science and Technology Commission of Shanghai Municipality

Youth Innovation Promotion Association of CAS

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

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