Inhibiting PHGDH with NCT-503 reroutes glucose-derived carbons into the TCA cycle, independently of its on-target effect-Reference-Cited by-同舟云学术

Inhibiting PHGDH with NCT-503 reroutes glucose-derived carbons into the TCA cycle, independently of its on-target effect

Published:2021-01-01 Issue:1 Volume:36 Page:1282-1289
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Arlt Birte¹²³⁴^ORCID,Mastrobuoni Guido⁴^ORCID,Wuenschel Jasmin¹²,Astrahantseff Kathy¹^ORCID,Eggert Angelika¹²⁵⁶^ORCID,Kempa Stefan³⁴⁵^ORCID,Deubzer Hedwig E.¹²³⁵⁶^ORCID

Affiliation:

1. Department of Pediatric Hematology and Oncology, Charité – Universitätsmedizin Berlin, Berlin, Germany

2. Neuroblastoma Research Group, Experimental and Clinical Research Center (ECRC) of the Charité and the Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany

3. Berlin Institute of Health (BIH), Berlin, Germany

4. Integrative Proteomics and Metabolomics, Berlin Institute for Medical Systems Biology at the Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

5. German Cancer Consortium (DKTK), Berlin, Germany

6. German Cancer Research Center (DKFZ), Heidelberg, Germany

Funder

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German Cancer Aid

Deutschen Konsortium für Translationale Krebsforschung

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2021.1935917