Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFR <sup>WT/</sup> EGFR <sup>T790M</sup> inhibitors-Reference-Cited by-同舟云学术

Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFR ^WT/ EGFR ^T790M inhibitors

Published:2023-05-31 Issue:1 Volume:38 Page:
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Al-Wahaibi Lamya H.¹,Mohammed Anber F.²,Abdel Rahman Fatema El-Zahraa S.³,Abdelrahman Mostafa H.⁴,Gu Xuyuan⁵,Trembleau Laurent⁵,Youssif Bahaa G. M.²

Affiliation:

1. Department of Chemistry, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia

2. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt

3. Department of Basic Sciences, Faculty of Oral and Dental Medicine, Nahda University, Beni-Suef, Egypt

4. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt

5. School of Natural and Computing Sciences, University of Aberdeen, Aberdeen, UK

Funder

Princess Nourah Bint Abdulrahman University Researchers

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2023.2218602

Reference40 articles.

1. Cancer incidence increasing globally: The role of relaxed natural selection

2. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety

4. Design and synthesis of new triarylimidazole derivatives as dual inhibitors of BRAFV600E/p38α with potential antiproliferative activity

5. Epidermal Growth Factor Receptor: Pathway, Therapies, and Pipeline

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