Synthesis, in silico modelling, and in vitro biological evaluation of substituted pyrazole derivatives as potential anti-skin cancer, anti-tyrosinase, and antioxidant agents

Author:

Boateng Samuel T.1,Roy Tithi1,Torrey Kara2,Owunna Uchechi3,Banang-Mbeumi Sergette14,Basnet David3,Niedda Eleonora5,Alexander Alexis D.1,Hage Denzel El3,Atchimnaidu Siriki3,Nagalo Bolni Marius67,Aryal Dinesh18,Findley Ann3,Seeram Navindra P.2,Efimova Tatiana9,Sechi Mario5,Hill Ronald A.1,Ma Hang2,Chamcheu Jean Christopher1ORCID,Murru Siva3ORCID

Affiliation:

1. School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA, USA

2. Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, Bioactive Botanical Research Laboratory, University of Rhode Island, Kingston, RI, USA

3. School of Sciences, College of Arts, Education and Sciences, University of Louisiana at Monroe, Monroe, LA, USA

4. School of Nursing and Allied Health Sciences, Louisiana Delta Community College, Monroe, LA, USA

5. Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy

6. Department of Pathology, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA

7. The Winthrop P. Rockefeller Cancer Institute, UAMS, Little Rock, AR, USA

8. Department of Biomedical Affairs and Research, Edward Via College of Osteopathic Medicine, Monroe, LA, USA

9. Department of Biomedical Engineering, Northwestern University, Chicago, IL, USA

Funder

Start-up funds from the University of Louisiana at Monroe (ULM) College of Pharmacy

ULMCOP Faculty Research Seed

National Institute of General Medical Sciences of the National Institutes of Health (NIGMS/NIH) NIGMS/NIH

Pilot and Full Research Project Grant Awards

IDeA Networks of Biomedical Research Excellence (INBRE)-Louisiana Biomedical Research Network

NIGMS/NIH

Louisiana Board of Regents Support Fund

National Center for Research Resources (NCRR) of the National Institutes of Health

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

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