Imparting aromaticity to 2-pyridone derivatives by <i>O</i> -alkylation resulted in new competitive and non-competitive PIM-1 kinase inhibitors with caspase-activated apoptosis-Reference-Cited by-同舟云学术

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Imparting aromaticity to 2-pyridone derivatives by O -alkylation resulted in new competitive and non-competitive PIM-1 kinase inhibitors with caspase-activated apoptosis

Published:2024-01-17 Issue:1 Volume:39 Page:
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Abdelaziz Marwa E.¹,El-Miligy Mostafa M. M.¹^ORCID,Fahmy Salwa M.¹,Abu-Serie Marwa M.²,Hazzaa Aly A.¹,Mahran Mona A.¹

Affiliation:

1. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

2. Medical Biotechnology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research and Technological Applications (SRTA-City), Alexandria, Egypt

Publisher

Informa UK Limited

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2024.2304044

Reference40 articles.

1. Pim1 Kinase Inhibitors Exert Anti-Cancer Activity Against HER2-Positive Breast Cancer Cells Through Downregulation of HER2

2. Inhibition of FLT3 and PIM Kinases by EC-70124 Exerts Potent Activity in Preclinical Models of Acute Myeloid Leukemia

3. Insights from Pim1 structure for anti-cancer drug design

4. Using Insights into Pim1 Structure to Design New Anticancer Drugs

5. Pim kinases in cancer: Diagnostic, prognostic and treatment opportunities

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