Design of new disubstituted imidazo[1,2-b]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation-Reference-Cited by-同舟云学术

Design of new disubstituted imidazo[1,2-b]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation

Published:2020-01-01 Issue:1 Volume:35 Page:1840-1853
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Elie Jonathan¹,Feizbakhsh Omid²,Desban Nathalie²,Josselin Béatrice²³,Baratte Blandine²³,Bescond Amandine²,Duez Julien²,Fant Xavier²,Bach Stéphane²³,Marie Dominique⁴,Place Matthieu¹,Ben Salah Sami¹,Chartier Agnes¹,Berteina-Raboin Sabine¹,Chaikuad Apirat⁵⁶,Knapp Stefan⁵⁶,Carles Fabrice¹,Bonnet Pascal¹,Buron Frédéric¹,Routier Sylvain¹,Ruchaud Sandrine²

Affiliation:

1. Institut de Chimie Organique et Analytique, Université d’Orléans, UMR CNRS 7311, Orléans Cedex 2, France

2. Sorbonne Université/CNRS UMR8227, Station Biologique, Roscoff cedex, France

3. Sorbonne Université/CNRS FR2424, Plateforme de criblage KISSf (Kinase Inhibitor Specialized Screening facility) Station Biologique, Roscoff cedex, France

4. Sorbonne Université/CNRS UMR7144, Station Biologique, Roscoff cedex, France

5. Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Frankfurt am Main, Germany

6. Structure Genomics Consortium, Johann Wolfgang Goethe University, Buchmann Institute for Molecular Life Sciences, Frankfurt am Main, Germany

Funder

la Ligue contre le Cancer du Grand-Ouest

Région Bretagne

Cancéropôle Grand Ouest

Marine Molecules, Metabolism and Cancer network

The Ministère de l’Enseignement, de la Recherche et de l’Innovation

Labex Synorg

IRON

SGC