Physiological Interpretation of Solute Transport Parameters for Peritoneal Dialysis

Abstract

A mathematical model for solute distribution within the tissue due to combined processes of diffusion and convective transport through the tissue, through the capillary wall, and by lymphatic absorption, during the exchange of the solute between an organ and external medium is applied for the description of the transport of small, middle and macro — molecules. The analytical solutions of the transport equations for the steady state are described. A parameter that characterizes the concentration profiles, the penetration depth, for combined diffusive and convective transport through the tissue is described as a function of the penetration depths for pure diffusive and pure convective transport components. The equation for the solute transport across the tissue surface is similar to a phenomenological formula widely used for the description of clinical and experimental peritoneal dwell studies. The phenomenological transport parameters may therefore be interpreted using the local transport coefficients for the tissue, the capillary wall, and lymphatic absorption. Theoretical estimations of those parameters are in good agreement with clinical data about solute transport in patients on continuous ambulatory peritoneal dialysis.