Bringing together scientific disciplines for collaborative undertakings: a vision for advancing the adverse outcome pathway framework

Author:

Chauhan Vinita1ORCID,Wilkins Ruth C.1ORCID,Beaton Danielle2ORCID,Sachana Magdalini3,Delrue Nathalie3,Yauk Carole4,O’Brien Jason5,Marchetti Francesco6ORCID,Halappanavar Sabina6,Boyd Michael7ORCID,Villeneuve Daniel8,Barton-Maclaren Tara S.6,Meek Bette9,Anghel Catalina2,Heghes Crina10,Barber Chris10,Perkins Edward11,Leblanc Julie12,Burtt Julie12ORCID,Laakso Holly2,Laurier Dominique13ORCID,Lazo Ted14,Whelan Maurice15,Thomas Russell16,Cool Donald17ORCID

Affiliation:

1. Consumer and Clinical Radiation Protection Bureau, Health Canada, Ottawa, Canada

2. Canadian Nuclear Laboratories, Chalk River, Canada

3. Environment Health and Safety Division, Environment Directorate, Organisation for Economic Co-operation and Development (OECD), Paris, France

4. Department of Biology, University of Ottawa, Ottawa, Canada

5. Ecotoxicology and Wildlife Health Division, Environment and Climate Change Canada, Ottawa, Canada

6. Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Canada

7. U.S. Environmental Protection Agency, Office of Air and Radiation, Washington, DC, USA

8. U.S. Environmental Protection Agency, Office of Research and Development, Duluth, MN, USA

9. McLaughlin Centre, University of Ottawa, Ottawa, Canada

10. Lhasa Limited, Leeds, UK

11. US Army Engineer Research and Development Center Jackson, Vicksburg, MS, USA

12. Directorate of Environment and Radiation Protection and Assessment, Canadian Nuclear Safety Commission, Ottawa, Canada

13. Health and Environment Division, Institute for Radiological Protection and Nuclear Safety (IRSN), Fontenay-aux-Roses, France

14. Radiological Protection and Human Aspects of Nuclear Safety Division, OECD Nuclear Energy Agency, Paris, France

15. European Commission, Joint Research Centre (JRC), Ispra, Italy

16. U.S. Environmental Protection Agency, Research Triangle Park, NC, USA

17. Electric Power Research Institute, Charlotte, NC, USA

Publisher

Informa UK Limited

Subject

Radiology, Nuclear Medicine and imaging,Radiological and Ultrasound Technology

Reference54 articles.

1. Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

2. Beyond adverse outcome pathways: making toxicity predictions from event networks, SAR models, data and knowledge

3. Barton-Maclaren T, Gwinn M, Thomas R, Kavlock R, Rasenberg M, Bloomberg Law, Environment & Energy Report. 2019. INSIGHT: new approaches to chemical assessment—a progress report. https://news.bloomberglaw.com/environment-and-energy/insight-new-approaches-to-chemical-assessment-a-progress-report.

4. Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence

5. Computed Tomography — An Increasing Source of Radiation Exposure

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