Implementing the meta-analytic approach for the evaluation of surrogate endpoints in SAS and R: a word of caution

Author:

Ong Fenny1ORCID,Wang Jingzhao2,Van der Elst Wim3ORCID,Verbeke Geert14ORCID,Molenberghs Geert14ORCID,Alonso Ariel4ORCID

Affiliation:

1. I-Biostat, Universiteit Hasselt, Diepenbeek, Belgium

2. Center for Drug Evaluation, NMPA, People’s Republic of China

3. The Janssen Pharmaceutical, companies of Johnson & Johnson, Beerse, B-2340, Belgium

4. I-BioStat, KU Leuven, Leuven, Belgium

Funder

Special Research Fund (BOF) of Hasselt University (BOF2OCPO3) and by GlaxoSmithKline Biologicals in the context of a civic PhD programme

Publisher

Informa UK Limited

Subject

Pharmacology (medical),Pharmacology,Statistics and Probability

Reference15 articles.

1. Bates, D., M. Maechler, B. Bolker, S. Walker, R. H. B. Christensen, H. Singmann, B. Dai, F. Scheipl, G. Grothendieck, P. Green, et al. lme4: linear mixed-effects models using ‘eigen’ and S4 (R Package Version 1.1-25). Accessed October 23, 2020. https://cran.r-project.org/web/packages/lme4/index.html

2. The Evaluation of Surrogate Endpoints

3. The validation of surrogate endpoints in meta-analyses of randomized experiments

4. Choice of units of analysis and modeling strategies in multilevel hierarchical models

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