1. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Nuffield Orthopaedic Centre, Oxford;
2. Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol;
3. Bradford Teaching Hospitals NHS Foundation Trust, St Luke’s Hospital, Bradford;
4. Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital and University of Leeds, Leeds;
5. National Institute for Health Research Bristol Biomedical Research Centre (NIHR Bristol BRC), University Hospitals Bristol NHS Foundation Trust, University of Bristol, Southmead Hospital, Bristol, UK