Safety and tolerability of AMG 330 in adults with relapsed/refractory AML: a phase 1a dose-escalation study

Author:

Ravandi Farhad1,Subklewe Marion23,Walter Roland B.4ORCID,Vachhani Pankit5,Ossenkoppele Gert6,Buecklein Veit23,Döhner Hartmut7,Jongen-Lavrencic Mojca8,Baldus Claudia D.9,Fransecky Lars9,Pardee Timothy S.10,Kantarjian Hagop1ORCID,Yen Priscilla K.11,Mukundan Lata12,Panwar Bharat12,Yago Marc R.12,Agarwal Suresh11,Khaldoyanidi Sophia K.11,Stein Anthony13

Affiliation:

1. Department of Leukemia, MD Anderson Cancer Center, Houston, TX, USA

2. Department of Medicine III, University Hospital, LMU Munich, Munich, Germany

3. Laboratory for Translational Research, Gene Center, LMU Munich, Munich, Germany

4. Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA

5. Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA

6. Amsterdam University Medical Center, Amsterdam, The Netherlands

7. Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

8. Department of Hematology, Erasmus University Medical Center Cancer Institute, Rotterdam, The Netherlands

9. Department of Internal Medicine II, University Hospital Schleswig-Holstein, Kiel, Germany

10. Department of Internal Medicine, Section on Hematology and Oncology, Atrium Health Wake Forest Baptist, Winston-Salem, NC, USA

11. Amgen Inc, Thousand Oaks, CA, USA

12. Amgen Inc, South San Francisco, CA, USA

13. Gehr Family Center for Leukemia Research, City of Hope National Medical Center, Duarte, CA, USA

Funder

Amgen Inc

Publisher

Informa UK Limited

Reference30 articles.

1. National Cancer Institute Surveillance Epidemiology and End Results Program. SEER Cancer Statistics Review (CSR) 1975-2017. https://seer.cancer.gov/csr/1975_2017/. Accessed March 28 2023.

2. National Cancer Institute Surveillance Epidemiology and End Results Program. Cancer Stat Facts: Leukemia–Acute Myeloid Leukemia (AML). https://seer.cancer.gov/statfacts/html/amyl.html. Accessed March 28 2023.

3. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

4. Emerging agents and regimens for treatment of relapsed and refractory acute myeloid leukemia

5. Acute Myeloid Leukemia

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