Severe pegaspargase hypersensitivity reaction rates (grade ≥3) with intravenous infusion vs. intramuscular injection: analysis of 54,280 doses administered to 16,534 patients on children’s oncology group (COG) clinical trials

Author:

Burke Michael J.1,Devidas Meenakshi2,Maloney Kelly3,Angiolillo Anne4,Schore Reuven4,Dunsmore Kimberly5,Larsen Eric6,Mattano Len A.7,Salzer Wanda8,Winter Stuart S.9,Carroll William10,Winick Naomi J.11,Loh Mignon L.12,Raetz Elizabeth13,Hunger Stephen P.14,Bleyer Archie15

Affiliation:

1. Medical College of Wisconsin and Children’s Hospital of Wisconsin, Milwaukee, WI, USA;

2. Department of Biostatistics, University of Florida, Gainesville, FL, USA;

3. School of Medicine and Children’s Hospital of Colorado, University of Colorado, Aurora, CO, USA;

4. Children’s National Medical Center, Washington, DC, USA;

5. University of Virginia Children’s Hospital, Charlottesville, VA, USA;

6. Maine Children’s Cancer Program, Scarborough, ME, USA;

7. HARP Pharma Consulting, Mystic, CT, USA;

8. US Army Medical Research and Materiel Command, Fort Detrick, MD, USA;

9. Health Sciences Center, University of New Mexico, Albuquerque, NM, USA;

10. Laura and Issac Perlmutter Cancer Center at NYU, New York, NY, USA;

11. Southwestern Simmons Cancer Center, University of Texas, Dallas, TX, USA;

12. Benioff Children’s Hospital, University of California San Francisco, San Francisco, CA, USA;

13. Department of Pediatrics, University of Utah, Salt Lake City, UT, USA;

14. Children’s Hospital of Philadelphia, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;

15. Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA

Publisher

Informa UK Limited

Subject

Cancer Research,Oncology,Hematology

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