The Use of Toxicokinetic Data in Preclinical Safety Assessment: A Toxicologic Pathologist Perspective-Reference-Cited by-同舟云学术

The Use of Toxicokinetic Data in Preclinical Safety Assessment: A Toxicologic Pathologist Perspective

Published:2007-10 Issue:6 Volume:35 Page:834-837
ISSN:0192-6233
Container-title:Toxicologic Pathology
language:en
Short-container-title:Toxicol Pathol

Author:

Ploemen Jan-Peter H. T. M.¹,Kramer Hester²,Krajnc Ernö I.¹,Martin Iain³

Affiliation:

1. Department of Toxicology & Drug Disposition, Organon, 5340 BH Oss, The Netherlands

2. Clinical Pharmacology & Kinetics, Organon, 5340 BH Oss, The Netherlands

3. Department of Pharmacology, Organon Research, Scotland

Abstract

Collection of toxicokinetic data has become a routine practice during the last 15 years in most general toxicity studies on pharma. It enables the correlation of pathological changes with the plasma concentration of drugs and/or their metabolites. This overview summarizes the use of the toxicokinetic data from the perspective of the toxicologic pathologist.

Publisher

SAGE Publications

Subject

Cell Biology,Toxicology,Molecular Biology,Pathology and Forensic Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1080/01926230701584247

Reference22 articles.

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