Effects of process parameters on tablet critical quality attributes in continuous direct compression: a case study of integrating data-driven statistical models and mechanistic compaction models-Reference-Cited by-同舟云学术

Effects of process parameters on tablet critical quality attributes in continuous direct compression: a case study of integrating data-driven statistical models and mechanistic compaction models

Published:2020-08-18 Issue:10 Volume:25 Page:1204-1215
ISSN:1083-7450
Container-title:Pharmaceutical Development and Technology
language:en
Short-container-title:Pharmaceutical Development and Technology

Author:

Huang Zhuangrong¹,Galbraith Shaun C.¹,Cha Bumjoon¹,Liu Huolong¹,Park Seoyoung¹,Flamm Matthew H.²,Metzger Matt³,Tantuccio Anthony³,Yoon Seongkyu¹

Affiliation:

1. Department of Chemical Engineering, University of Massachusetts Lowell, Lowell, MA, USA

2. Applied Mathematics and Modeling, Scientific Modeling Platforms, Merck & Co., Inc, Kenilworth, NJ, USA

3. Pharmaceutical Commercialization Technology, Merck & Co., Inc, Kenilworth, NJ, USA

Funder

U.S. FDA cooperative research project

Merck Sharp & Dohme Corp

Merck & Co., Inc

Publisher

Informa UK Limited

Subject

Pharmaceutical Science,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/10837450.2020.1805760

Reference29 articles.

1. Computer-Aided Flowsheet Simulation of a Pharmaceutical Tablet Manufacturing Process Incorporating Wet Granulation

2. An integrated approach for dynamic flowsheet modeling and sensitivity analysis of a continuous tablet manufacturing process

3. Modeling the effects of material properties on tablet compaction: A building block for controlling both batch and continuous pharmaceutical manufacturing processes

4. Modeling and simulation of continuous powder blending applied to a continuous direct compression process

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2. Reduced-order hybrid modelling for powder compaction: Predicting density and classifying diametrical hardness;Powder Technology;2023-09

3. Optimization of Critical Quality Attributes in Tablet Film Coating and Design Space Determination Using Pilot-Scale Experimental Data;AAPS PharmSciTech;2021-01