Optimization of nimesulide-loaded solid lipid nanoparticles (SLN) by factorial design, release profile and cytotoxicity in human Colon adenocarcinoma cell line

Author:

Campos Joana R.1,Fernandes Ana R.1,Sousa Raquel1,Fangueiro Joana F.1,Boonme Prapaporn23,Garcia Maria Luisa45,Silva Amelia M.67,Naveros Beatriz C.8,Souto Eliana B.19ORCID

Affiliation:

1. Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Pólo das Ciências da Saúde, Azinhaga de Santa Comba, Coimbra, Portugal;

2. Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla, Thailand;

3. Nanotec-PSU Center of Excellence on Drug Delivery System, Songkhla, Thailand;

4. Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain;

5. Institute of Nanoscience and Nanotechnology, University of Barcelona, Barcelona, Spain;

6. Department of Biology and Environment, University of Trás-os-Montes e Alto Douro, UTAD, Quinta de Prados, Vila Real, Portugal;

7. Centre for Research and Technology of Agro-Environmental and Biological Sciences, CITAB, UTAD, Quinta de Prados, Vila Real, Portugal;

8. Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Granada, Spain;

9. CEB - Centre of Biological Engineering, University of Minho, Campus de Gualtar, Braga, Portugal

Funder

FEDER

Spanish Ministry of Science and Innovation

Publisher

Informa UK Limited

Subject

Pharmaceutical Science,General Medicine

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