Mechanistic evidence from classical molecular dynamics and metadynamics revealed the mechanism of resistance to 4-hydroxy tamoxifen in estrogen receptor alpha Y537S mutant-Reference-Cited by-同舟云学术

Mechanistic evidence from classical molecular dynamics and metadynamics revealed the mechanism of resistance to 4-hydroxy tamoxifen in estrogen receptor alpha Y537S mutant

Published:2022-07-12 Issue:16 Volume:48 Page:1456-1463
ISSN:0892-7022
Container-title:Molecular Simulation
language:en
Short-container-title:Molecular Simulation

Author:

Bouricha El Mehdi¹,Hakmi Mohammed¹,Kartti Souad¹,Zouaidia Fouad²,Ibrahimi Azeddine¹^ORCID

Affiliation:

1. Medical Biotechnology Laboratory (MedBiotech), Rabat Medical & Pharmacy School, Mohammed Vth University in Rabat, Rabat, Morocco

2. Department of pathology, Ibn Sina University Hospital Center, Rabat, Morocco

Funder

Moroccan Ministry of Higher Education and Scientific Research

Institute of Cancer Research

PPR-1 program

Publisher

Informa UK Limited

Subject

Condensed Matter Physics,General Materials Science,General Chemical Engineering,Modeling and Simulation,Information Systems,General Chemistry

Link

https://www.tandfonline.com/doi/pdf/10.1080/08927022.2022.2097283

Reference28 articles.

1. Correlations between estrogen receptor, progesterone receptor, and patient characteristics in human breast cancer.

2. Nuclear-Receptor Ligands and Ligand-Binding Domains

3. Estrogen Receptor Activation Function 1 Works by Binding p160 Coactivator Proteins

4. Mechanisms of Endocrine Resistance in Breast Cancer

5. Estrogen Receptors as Therapeutic Targets in Breast Cancer

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