Local delivery of interleukin 7 with an oncolytic adenovirus activates tumor-infiltrating lymphocytes and causes tumor regression

Author:

Kudling Tatiana V.1,Clubb James H.A.12,Quixabeira Dafne C.A.1,Santos Joao M.12,Havunen Riikka12,Kononov Alexander3,Heiniö Camilla1,Cervera-Carrascon Victor12,Pakola Santeri14,Basnet Saru1,Grönberg-Vähä-Koskela Susanna14,Arias Victor1,Gladwyn-Ng Ivan5,Aro Katri46,Bäck Leif46,Räsänen Jari7,Ilonen Ilkka7,Borenius Kristian7,Räsänen Mikko7,Hemminki Otto48,Rannikko Antti48,Kanerva Anna149,Tapper Johanna49,Hemminki Akseli124ORCID

Affiliation:

1. Cancer Gene Therapy Group, Translational Immunology Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

2. TILT Biotherapeutics Ltd, Helsinki, Finland

3. Systems Oncology Group, Cancer research UK, Manchester University, Manchester, UK

4. Comprehensive Cancer Center, Helsinki University Hospital (HUS), Helsinki, Finland

5. Taconic Biosciences GmbH, Leverkusen, Germany

6. Department of Otorhinolaryngology – Head and Neck Surgery, Helsinki Head and Neck Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland

7. Department of Thoracic Surgery, Heart and Lung Center, Helsinki University Hospital and Faculty of Medicine, University of Helsinki, Helsinki, Finland

8. Department of Urology, Helsinki University Hospital, Helsinki, Finland

9. Department of Gynecology and Obstetrics, Helsinki University Hospital, Helsinki, Finland

Funder

Doctoral programme in clinical research

TILT Biotherapeutics Ltd

Suomen Kulttuurirahasto

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

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