Long-peptide vaccination with driver gene mutations in p53 and Kras induces cancer mutation-specific effector as well as regulatory T cell responses

Author:

Quandt Jasmin12,Schlude Christoph1,Bartoschek Michael13ORCID,Will Rainer4,Cid-Arregui Angel15,Schölch Sebastian67ORCID,Reissfelder Christoph67,Weitz Jürgen8,Schneider Martin6,Wiemann Stefan49ORCID,Momburg Frank110,Beckhove Philipp111

Affiliation:

1. Department of Translational Immunology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany

2. Knapp Research Center, Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA

3. Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Lund, Sweden

4. Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany

5. Targeted Tumor Vaccines Group, Clinical Cooperation Unit Applied Tumor Immunity, German Cancer Research Center (DKFZ), Heidelberg, Germany

6. Department of Visceral Surgery, University Hospital Heidelberg, Heidelberg, Germany

7. Department of Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

8. Department of Visceral, Thoracic, and Vascular Surgery, Medizinische Fakultaet an der TU-Dresden, Dresden, Germany

9. Division Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany

10. Antigen Presentation and T/NK Cell Activation Group, Clinical Cooperation Unit Applied Tumor Immunity, German Cancer Research Center (DKFZ), Heidelberg, Germany

11. Regensburg Center for Interventional Immunology (RCI), University Regensburg and Department of Hematology-Oncology, Internal Medicine III, University Hospital Regensburg, Regensburg, Germany

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

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