Cross-talk between allosteric and orthosteric binding sites of γ-amino butyric acid type A receptors (GABAA-Rs): A computational study revealing the structural basis of selectivity-Reference-Cited by-同舟云学术

Cross-talk between allosteric and orthosteric binding sites of γ-amino butyric acid type A receptors (GABAA-Rs): A computational study revealing the structural basis of selectivity

Published:2019-01-04 Issue:12 Volume:37 Page:3065-3080
ISSN:0739-1102
Container-title:Journal of Biomolecular Structure and Dynamics
language:en
Short-container-title:Journal of Biomolecular Structure and Dynamics

Author:

Payghan Pavan V.¹,Nath Roy Sudipendra²,Bhattacharyya Dhananjay³,Ghoshal Nanda¹

Affiliation:

1. Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India;

2. National Institute of Pharmaceutical Education and Research, Kolkata, India;

3. Computational Science Division, Saha Institute of Nuclear Physics, Kolkata, India

Funder

Council of Scientific and Industrial Research

Publisher

Informa UK Limited

Subject

Molecular Biology,General Medicine,Structural Biology

Link

https://www.tandfonline.com/doi/pdf/10.1080/07391102.2018.1508367

Reference114 articles.

1. Analysis of Differential Efficacy and Affinity of GABAA (α1/α2) Selective Modulators

2. Development and SAR of functionally selective allosteric modulators of GABAA receptors

3. Two Tyrosine Residues on the α Subunit Are Crucial for Benzodiazepine Binding and Allosteric Modulation of γ-Aminobutyric AcidA Receptors

4. GABAAReceptor Subtype-Selective Efficacy: TPA023, an α2/α3 Selective Non-sedating Anxiolytic and α5IA, an α5 Selective Cognition Enhancer

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Epileptic Encephalopathy GABRB Structural Variants Share Common Gating and Trafficking Defects;Biomolecules;2023-12-14

2. Structure-function Studies of GABA (A) Receptors and Related computer-aided Studies;Journal of Molecular Neuroscience;2023-09-26

3. Commentary on Alleviation of anxiety: the benzodiazepine saga by Willy Haefely;Discoveries in Pharmacology;2023

4. Evaluation of anti-bacterial activity of novel 2, 3-diaminoquinoxaline derivatives: design, synthesis, biological screening, and molecular modeling studies;Egyptian Journal of Basic and Applied Sciences;2022-03-30

5. Use of Molecular Dynamics Simulations in Structure-Based Drug Discovery;Current Pharmaceutical Design;2019-11-14