Development of a novel apigenin prodrug programmed for alkaline-phosphatase instructed self-inhibition to combat cancer

Author:

Diamantis Dimitrios1,Tsiailanis Antonios D.1,Papaemmanouil Christina1,Nika Maria-Christina2,Kanaki Zoi3,Golic Grdadolnik Simona4,Babic Andrej5,Tzakos Eleftherios Paraskevas6,Fournier Isabelle78,Salzet Michel78,Kushwaha Prem Prakash9,Thomaidis Nikolaos S.2,Rampias Theodoros3,Shankar Eswar9,Karakurt Serdar10,Gupta Sanjay9,Tzakos Andreas G.111

Affiliation:

1. Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, Ioannina, Greece

2. Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Athens, Greece

3. Biomedical Research Foundation Academy of Athens, Athens, Greece

4. Laboratory for Molecular Structural Dynamics, Theory Department, National Institute of Chemistry, Ljubljana, Slovenia

5. School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland

6. Department of Biology, National and Kapodistrian University of Athens, Greece

7. Univ. Lille, Inserm, U-1192 - Laboratoire Protéomique, Lille, France

8. Institut Universitaire de France, Paris

9. Department of Urology, Case Western Reserve University & University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA

10. Department of Biochemistry, Selcuk University, Konya, Turkey

11. Institute of Materials Science and Computing, University Research Center of Ioannina (URCI), Ioannina, Greece

Funder

Slovenian Research Agency

Hellenic Foundation for Research and Innovation

Research Foundation of Selcuk University

The research work was supported by the Hellenic Foundation for Research and Innovation (HFRI) under the HFRI PhD Fellowship grants

State Scholarships Foundation

VA Merit Review

Department of Defense

Publisher

Informa UK Limited

Subject

Molecular Biology,General Medicine,Structural Biology

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