The effects of aging on hepatic microsomal scaling factor and hepatocellularity number in the horse
Author:
Affiliation:
1. School of Veterinary Medicine and Sciences, University of Nottingham , Sutton Bonington , Leicestershire , UK and
2. Departement of Internal Medicine, Faculty of Veterinary Medicine, University of Tripoli , Tripoli , Libya
Publisher
Informa UK Limited
Subject
Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine
Link
https://www.tandfonline.com/doi/pdf/10.1080/00498254.2017.1413263
Reference42 articles.
1. Preparation of equine isolated hepatocytes
2. Scaling Factors for the Extrapolation of In Vivo Metabolic Drug Clearance From In Vitro Data: Reaching a Consensus on Values of Human Micro-somal Protein and Hepatocellularity Per Gram of Liver
3. Covariation of Human Microsomal Protein Per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data Pooling
4. Effect of development on the activity of microsomal drug-metabolizing enzymes in rat liver
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1. Parameterization of Microsomal and Cytosolic Scaling Factors: Methodological and Biological Considerations for Scalar Derivation and Validation;European Journal of Drug Metabolism and Pharmacokinetics;2020-12-19
2. Prediction of pharmacokinetic clearance and potential Drug-Drug interactions for omeprazole in the horse using in vitro systems;Xenobiotica;2020-05-20
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