19F-NMR-based determination of the absorption, metabolism and excretion of the oral phosphatidylinositol-3-kinase (PI3K) delta inhibitor leniolisib (CDZ173) in healthy volunteers
Author:
Affiliation:
1. Pharmacokinetic Sciences, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland;
2. Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
Publisher
Informa UK Limited
Subject
Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine
Link
https://www.tandfonline.com/doi/pdf/10.1080/00498254.2018.1523488
Reference24 articles.
1. Design of A Metabolically Stable Tritium-Tracer of the PI3Kδ-Inhibitor CDZ173 (Leniolisib) as a Tool to Study Liver Metabolites
2. Human absorption, distribution, metabolism and excretion properties of drug molecules: a plethora of approaches
3. Biotransformation and bioactivation reactions of alicyclic amines in drug molecules
4. CYP3A but not P-gp plays a relevant role in the in vivo intestinal and hepatic clearance of the delta-specific phosphoinositide-3 kinase inhibitor leniolisib
5. Metabolism of 3-chloro-4-fluoroaniline in rat using [14C]-radiolabelling,19F-NMR spectroscopy, HPLC-MS/MS, HPLC-ICPMS and HPLC-NMR
Cited by 9 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Meeting report of the 4th European biotransformation workshop;Xenobiotica;2024-01-04
2. Biotransformation research advances – 2022 year in review;Drug Metabolism Reviews;2023-10-02
3. Discovery of novel pyrido[3,2‐d]pyrimidine derivatives as selective and potent PI3Kδ inhibitors;Drug Development Research;2023-09-21
4. Human Absorption, Distribution, Metabolism, and Excretion Studies: Origins, Innovations, and Importance;Drug Metabolism and Disposition;2023-03-27
5. Design, conduct, and interpretation of human mass balance studies and strategies for assessing metabolites-in-safety testing (MIST) in drug development;Overcoming Obstacles in Drug Discovery and Development;2023
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3