SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species-Reference-Cited by-同舟云学术

SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species

Published:2021-01-01 Issue:1 Volume:10 Page:178-195
ISSN:2222-1751
Container-title:Emerging Microbes & Infections
language:en
Short-container-title:Emerging Microbes & Infections

Author:

Moustaqil Mehdi¹,Ollivier Emma¹^ORCID,Chiu Hsin-Ping²,Van Tol Sarah³,Rudolffi-Soto Paulina¹,Stevens Christian²,Bhumkar Akshay¹,Hunter Dominic J. B.¹⁴,Freiberg Alexander N.⁵,Jacques David¹,Lee Benhur²^ORCID,Sierecki Emma¹,Gambin Yann¹

Affiliation:

1. EMBL Australia Node for Single Molecule Sciences, and School of Medical Sciences, Botany Road, The University of New South Wales, Sydney, Australia

2. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

3. Department of Microbiology and Immunology, Institute for Human Infections and Immunity, The University of Texas Medical Branch, Galveston, TX, USA

4. Institute for Molecular Biosciences, The University of Queensland, St Lucia, Australia

5. Department of Pathology, Institute for Human Infections and Immunity, The University of Texas Medical Branch, Galveston, TX, USA

Publisher

Informa UK Limited

Subject

Virology,Infectious Diseases,Drug Discovery,General Medicine,Immunology,Microbiology,Parasitology,Epidemiology

Link

https://www.tandfonline.com/doi/pdf/10.1080/22221751.2020.1870414

Reference85 articles.

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2. Human coronaviruses with emphasis on the COVID-19 outbreak

3. Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2

4. Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

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