Rational design of an influenza-COVID-19 chimeric protective vaccine with HA-stalk and S-RBD

Author:

Li Yulei1ORCID,Liu Peipei2,Hao Tianjiao34,Liu Sheng5,Wang Xi34,Xie Yufeng6,Xu Ke2,Lei Wenwen2,Zhang Cheng7ORCID,Han Pu3,Li Ying1,Jin Xiyue8,Huan Yu34,Lu Yafei34,Zhang Rong9,Li Xiaoyan10,Zhao Xin3,Xu Kun11ORCID,Liao Pu12,Lu Xuancheng10,Bi Yuhai34,Song Hao411ORCID,Wu Guizhen2,Zhu Baoli3413,Gao George F.12311ORCID

Affiliation:

1. Savaid Medical School, University of Chinese Academy of Sciences, Beijing, People’s Republic of China

2. NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China

3. CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People’s Republic of China

4. University of Chinese Academy of Sciences, Beijing, People’s Republic of China

5. Cryo-EM Center, Southern University of Science and Technology, Shenzhen, People’s Republic of China

6. Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, People’s Republic of China

7. Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi, People’s Republic of China

8. School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, People’s Republic of China

9. State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, People’s Republic of China

10. Laboratory Animal Center, Chinese Center for Disease Control and Prevention (China CDC), Beijing, People’s Republic of China

11. Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, People’s Republic of China

12. Department of Clinical Laboratory, Chongqing General Hospital, Chongqing, People’s Republic of China

13. Department of Pathogenic Biology, School of Basic Medical Sciences, Southwest Medical University, Luzhou, People’s Republic of China

Funder

National Key Research and Development Program of China

CAS Project for Young Scientists in Basic Research

the National Natural Science Foundation of China

National Key Research and Development Projects of the Ministry of Science and Technology of China

the Strategic Priority Research Program of CAS

Publisher

Informa UK Limited

Subject

Virology,Infectious Diseases,Drug Discovery,General Medicine,Immunology,Microbiology,Parasitology,Epidemiology

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