Novel recombinant vaccinia virus-vectored vaccine affords complete protection against homologous Borrelia burgdorferi infection in mice

Author:

Pfeifle Annabelle12,Zhang Wanyue12,Cao Jingxin3,Thulasi Raman Sathya N.1,Anderson-Duvall Rose12,Tamming Levi12,Gravel Caroline1,Coatsworth Heather3,Chen Wangxue4,Johnston Michael JW15,Sauve Simon1,Rosu-Myles Michael1,Wang Lisheng2,Li Xuguang12

Affiliation:

1. Centre for Oncology, Radiopharmaceuticals and Research, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada and World Health Organization Collaborating Center for Standardization and Evaluation of Biologicals, Ottawa, ON, Canada

2. Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada

3. National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada

4. Human Health Therapeutics Research Center, National Research Council of Canada, Ottawa, ON, Canada

5. Department of Chemistry, Carleton University, Ottawa, ON, Canada

Publisher

Informa UK Limited

Reference63 articles.

1. Kugeler KJ Schwartz AM Delorey MJ et al. Estimating the Frequency of Lyme Disease Diagnoses United States 2010-2018. Emerg Infect Dis [Internet]. 2021;27:616–619. Available from: http://www.ncbi.nlm.nih.gov/pubmed/33496229.

2. Government of Canada. Lyme disease: Surveillance [Internet]. 2024 [cited 2024 May 13]. Available from: https://www.canada.ca/en/public-health/services/diseases/lyme-disease/surveillance-lyme-disease.html.

3. Brownstein JS Holford TR Fish D. Effect of climate change on lyme disease risk in North America. Ecohealth. 2005;2:38–46.

4. Steere AC Sikand VK. The Presenting Manifestations of Lyme Disease and the Outcomes of Treatment. N Engl J Med [Internet]. 2003 [cited 2020 Nov 30];348:2472–2474. Available from: https://www.nejm.org/doi/full/10.1056NEJM200306123482423.

5. United States Environmental Protection Agency. Climate Change Indicators: Lyme Disease [Internet]. 2023 [cited 2024 May 13]. Available from: https://www.epa.gov/climate-indicators/climate-change-indicators-lyme-disease.

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