Deciphering lung granulomas in HIV & TB co-infection: unveiling macrophages aggregation with IL6R/STAT3 activation

Author:

Li Qian1,Wang Cheng1,Gou Jizhou2,Kitanovski Simo3,Tang XiangYi1,Cai Yixuan4,Zhang Chenxia4,Zhang Xiling1,Zhang Zhenfeng5,Qiu Yuanwang4,Zhao Fang1,Lu Mengji6ORCID,He Yun1,Wang Jun134,Lu Hongzhou1

Affiliation:

1. National Clinical Research Center for Infectious Diseases, The Third People’s Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, People’s Republic of China

2. Department of Pathology, National Clinical Research Center for Infectious Diseases, Shenzhen Third People’s Hospital, Shenzhen, People’s Republic of China

3. Bioinformatics and Computational Biophysics, University of Duisburg-Essen, Essen, Germany

4. Clinical Research Center, The Fifth People’s Hospital of Wuxi, Jiangnan University, Wuxi, People’s Republic of China

5. School of Public Health and Emergency Management, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, People’s Republic of China

6. Institute of Virology, Essen University Hospital, University of Duisburg-Essen, Essen, German

Funder

China's National Key

R&D Programs

National Science Foundation of China

Chinesisch-Deutsches Mobilitats programm

Basic and Applied Basic Research Fund of Guangdong Province: Regional Joint Fund-Youth Fund Project

China Post-Doctoral Science Foundation

Shenzhen Third People’ s Hospital project

Shenzhen Clinical Research Center for Tuberculosis

Shenzhen Science and Technology Innovations Committee

Top Talent Support Program for young and middle-aged people of Wuxi Health Committee

Research Projects of Wuxi Health Committee

Wuxi Science and Technology Fund Project

Publisher

Informa UK Limited

Reference48 articles.

1. World Health Organization. Global TB report 2022 [cited 2024 March 24]. Available from: https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2022

2. Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection

3. Centers for Disease Control and Prevention. TB and HIV Coinfection [cited 2024 March 24]. Available from: https://www.cdc.gov/tb/topic/basics/tbhivcoinfection.htm

4. The Role of the Granuloma in Expansion and Dissemination of Early Tuberculous Infection

5. Inflammatory signaling in human tuberculosis granulomas is spatially organized

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