Insights into the operational model of agonism of receptor dimers
Author:
Affiliation:
1. Laboratory of Neurochemistry, Institute of Physiology CAS, Prague, Czech Republic
Funder
the Czech Science Foundation grant
the Czech Academy of Sciences institutional support
Publisher
Informa UK Limited
Subject
Drug Discovery
Link
https://www.tandfonline.com/doi/pdf/10.1080/17460441.2023.2147502
Reference63 articles.
1. Efficacy in drug receptor theory: outdated concept or under-valued tool?
2. Operational models of pharmacological agonism
3. An operational model of pharmacological agonism: the effect of E/[A] curve shape on agonist dissociation constant estimation
4. A Simple Method for Quantifying Functional Selectivity and Agonist Bias
5. Functional Selectivity and Biased Receptor Signaling
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1. Agonist-selective activation of individual G-proteins by muscarinic receptors;Scientific Reports;2024-04-26
2. A critical re-evaluation of the slope factor of the operational model of agonism: When to exponentiate operational efficacy;Scientific Reports;2023-10-16
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