An engineered human IgG1 CH2 domain with decreased aggregation and nonspecific binding-Reference-Cited by-同舟云学术

An engineered human IgG1 CH2 domain with decreased aggregation and nonspecific binding

Published:2019-12-03 Issue:1 Volume:12 Page:
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Cao Guangcan¹²,Gao Xinyu¹²,Zhan Yancheng¹²,Wang Qingguang¹²,Zhang Zhe¹,Dimitrov Dimiter S.³,Gong Rui¹

Affiliation:

1. CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China

2. University of Chinese Academy of Sciences, Beijing, China

3. Center for Antibody Therapeutics, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania, USA

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hubei Province of China

“One-Three-Five” Strategic Programs of Wuhan Institute of Virology, Chinese Academy of Sciences

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2019.1689027

Reference45 articles.

1. Therapeutic antibodies, vaccines and antibodyomes

2. Challenges in the development of high protein concentration formulations

3. Aggregation in Protein-Based Biotherapeutics: Computational Studies and Tools to Identify Aggregation-Prone Regions

4. Post-production protein stability: trouble beyond the cell factory

5. Monoclonal Antibodies Follow Distinct Aggregation Pathways During Production-Relevant Acidic Incubation and Neutralization

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