Biomeasures and mechanistic modeling highlight PK/PD risks for a monoclonal antibody targeting Fn14 in kidney disease-Reference-Cited by-同舟云学术

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Biomeasures and mechanistic modeling highlight PK/PD risks for a monoclonal antibody targeting Fn14 in kidney disease

Published:2017-11-30 Issue:1 Volume:10 Page:62-70
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Chen Xiaoying¹,Farrokhi Vahid²,Singh Pratap²,Ocana Mireia Fernandez²,Patel Jenil²,Lin Lih-Ling³,Neubert Hendrik²,Brodfuehrer Joanne¹

Affiliation:

1. Department of Biomedicine Design, Pfizer Inc, Cambridge, MA, United States of America

2. Department of Biomedicine Design, Pfizer Inc, Andover, MA, United States of America

3. Inflammation and Immunology Research Unit, Pfizer Inc., Cambridge, MA, United States of America

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2017.1398873

Reference52 articles.

1. Translational pharmacokinetics and pharmacodynamics of monoclonal antibodies

2. Quantitative Analysis of Target Coverage and Germinal Center Response by a CXCL13 Neutralizing Antibody in a T-Dependent Mouse Immunization Model

3. A Novel TNF Receptor Family Member Binds TWEAK and Is Implicated in Angiogenesis

4. The TWEAK–Fn14 cytokine–receptor axis: discovery, biology and therapeutic targeting

5. Fibroblast Growth Factor-Inducible 14 Mediates Multiple Pathways of TWEAK-Induced Cell Death

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1. Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity;EMBO Molecular Medicine;2022-09-07

2. Prominin‐1‐expressing hepatic progenitor cells induce fibrogenesis in murine cholestatic liver injury;Physiological Reports;2020-07

3. Involvement of NF-κB1 and the Non-canonical NF-κB Signaling Pathway in the Pathogenesis of Acute Kidney Injury in Shiga-toxin-2-induced Hemolytic-uremic Syndrome in Mice;Shock;2020-05-15

4. Protein Biomarker Quantification by Immunoaffinity Liquid Chromatography–Tandem Mass Spectrometry: Current State and Future Vision;Clinical Chemistry;2020-01-30

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