Insight into the avidity–affinity relationship of the bivalent, pH-dependent interaction between IgG and FcRn-Reference-Cited by-同舟云学术

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Insight into the avidity–affinity relationship of the bivalent, pH-dependent interaction between IgG and FcRn

Published:2024-06-07 Issue:1 Volume:16 Page:
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Reusch Johannes¹²,Andersen Jan Terje³⁴⁵,Rant Ulrich¹,Schlothauer Tilman²^ORCID

Affiliation:

1. Dynamic Biosensors GmbH, Munich, Germany

2. Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Munich, Roche Diagnostics GmbH, Penzberg, Germany

3. Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway

4. Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway

5. Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway

Publisher

Informa UK Limited

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2024.2361585

Reference77 articles.

1. Development trends for human monoclonal antibody therapeutics

2. Antibodies to watch in 2022

3. Pharmacokinetic de-risking tools for selection of monoclonal antibody lead candidates

4. Selection of bispecific antibodies with optimal developability using FcRn‑pH‑HPLC as an optimized FcRn affinity chromatography method

5. Assessing developability early in the discovery process for novel biologics

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