Untargeted proteomics reveals upregulation of stress response pathways during CHO-based monoclonal antibody manufacturing process leading to disulfide bond reduction-Reference-Cited by-同舟云学术

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Untargeted proteomics reveals upregulation of stress response pathways during CHO-based monoclonal antibody manufacturing process leading to disulfide bond reduction

Published:2021-01-01 Issue:1 Volume:13 Page:
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Park Seo-Young¹²^ORCID,Egan Susan³,Cura Anthony J.³,Aron Kathryn L.³,Xu Xuankuo³^ORCID,Zheng Mengyuan³,Borys Michael³,Ghose Sanchayita³,Li Zhengjian³^ORCID,Lee Kyongbum¹^ORCID

Affiliation:

1. Department of Chemical and Biological Engineering, Tufts University, Medford, MA, USA

2. School of Chemical Engineering, Sungkyunkwan University, Suwon, Republic of Korea

3. Biologics Development, Global Product Development and Supply, Bristol-Myers Squibb, Devens, USA

Funder

Bristol–Myers Squibb

National Science Foundation

National Institutes of Health

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2021.1963094

Reference62 articles.

1. Mammalian Systems Biotechnology Reveals Global Cellular Adaptations in a Recombinant CHO Cell Line

2. Process Analytical Technology and Quality by Design for Animal Cell Culture

3. Bigdata analytics identifies metabolic inhibitors and promoters for productivity improvement and optimization of monoclonal antibody (mAb) production process

4. Stress Factors in mAb Drug Substance Production Processes: Critical Assessment of Impact on Product Quality and Control Strategy

5. Identification and control of novel growth inhibitors in fed-batch cultures of Chinese hamster ovary cells

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2. Adaptive modeling optimized by the data fusion strategy: Real‐time dying cell percentage prediction using capacitance spectroscopy;Biotechnology Progress;2024-01-04

3. New high-throughput screening method for Chinese hamster ovary cell lines expressing low reduced monoclonal antibody levels: application of a system controlling the gas phase over cell lysates in miniature bioreactors and facilitating multiple sample setup;Cytotechnology;2023-07-21

4. Data‐driven prediction models for forecasting multistep ahead profiles of mammalian cell culture toward bioprocess digital twins;Biotechnology and Bioengineering;2023-04-20

5. New high-throughput screening method for Chinese hamster ovary cell lines expressing low reduced monoclonal antibody levels: Application of a system controlling the gas phase over cell lysates in miniature bioreactors and facilitating multiple sample setup;2023-02-03

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