Randomized Controlled Trial of Olanzapine in the Treatment of Cognitions in Anorexia Nervosa

Abstract

Objective: Recovery from anorexia nervosa is confounded by intrusive anorec-tic cognitions and rituals. It has been observed that olanzapine, an atypical antipsychotic, can reduce this anorexic rumination. A pilot study was designed to test the effectiveness of olanzapine in this role. Methods: A randomized trial of olanzapine versus chlorpromazine, with anorexic rumination as the primary outcome, was conducted. Of the 26 patients who presented, 15 were randomized in a balanced block design, eight to olanzapine and seven to chlorpromazine. Results: Only the olanzapine group had a significant reduction in the degree of rumination. Conclusion: Olanzapine may be of benefit in anorexia nervosa by causing a reduction in anorexic rumination.