In-vivo anti-epileptic study of newly synthesized pregabalin derivatives based on docking studies

Author:

Asbat Ayesha1ORCID,Saleem Farooq1,Najm Saima2,Iqbal Javed1,Syed Muhammad Ali1,Azeem Muhammad1,Asbat Syeda Javeria3,Shoukat Sadia1

Affiliation:

1. Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan

2. Faculty of Pharmacy, Lahore College of Pharmaceutical Sciences, Lahore, Pakistan

3. Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan

Funder

no funding associated

Publisher

Informa UK Limited

Subject

Neurology (clinical),Neurology,General Medicine

Reference15 articles.

1. Novel cyclopropyl δ-amino acid analogues of pregabalin and gabapentin that target the r2-δ protein;Jacob B;J Med Chem,2004

2. Molecular targets versus models for new antiepileptic drug discovery

3. Pharmacological models of generalized absence seizures in rodents;Snead OC;J Neural Transm,1992

4. Comparison of maximal seizures evoked by pentylenetetrazol (metrazol) and electroshock in mice, and their modification by anticonvulsants;Goodman LS;J Pharmacol Exp Ther,1953

5. Kinetics of drug action in disease states. XIV. effect of infusion rate on pentylenetetrazol concentrations in serum, brain and cerebrospinal fluid of rats at onset of convulsions;Ramzan IM;J Pharmacol Exp Ther,1985

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