Characterising diflunisal as a transthyretin kinetic stabilizer at relevant concentrations in human plasma using subunit exchange-Reference-Cited by-同舟云学术

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Characterising diflunisal as a transthyretin kinetic stabilizer at relevant concentrations in human plasma using subunit exchange

Published:2022-11-29 Issue: Volume: Page:1-5
ISSN:1350-6129
Container-title:Amyloid
language:en
Short-container-title:Amyloid

Author:

Tsai Felix J.¹,Nelson Luke T.¹,Kline Gabriel M.¹,Jäger Marcus¹,Berk John L.²^ORCID,Sekijima Yoshiki³^ORCID,Powers Evan T.¹,Kelly Jeffery W.¹⁴^ORCID

Affiliation:

1. Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA

2. Boston University Amyloidosis Center, Boston, MA, USA

3. Department of Medicine (Neurology & Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan

4. The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA

Funder

NIH

Publisher

Informa UK Limited

Subject

Internal Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/13506129.2022.2148094

Reference28 articles.

1. Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro

2. The Acid-Mediated Denaturation Pathway of Transthyretin Yields a Conformational Intermediate That Can Self-Assemble into Amyloid

3. Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity

4. An Engineered Transthyretin Monomer that Is Nonamyloidogenic, Unless It Is Partially Denatured

5. Kinetic Stabilization of an Oligomeric Protein under Physiological Conditions Demonstrated by a Lack of Subunit Exchange: Implications for Transthyretin Amyloidosis

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Unraveling the effect of molecular medium on the fluorosolvatochromism of the biphenyl- salicylate derivative drug Diflunisal: Experimental and computational study;Journal of Molecular Liquids;2024-09

2. Two Small Molecule Drugs with Topical Applications, Diflunisal and Naphazoline, and Their Potentially Toxic Photodegradants: Analysis by Chemical and Biological Methods;Molecules;2024-08-30

3. Effect of Diflunisal in Patients with Transthyretin Cardiomyopathy: A Pilot Study;Journal of Clinical Medicine;2024-08-25

4. Diflunisal versus tafamidis on neuropathy and cardiomyopathy in hereditary transthyretin amyloidosis;Annals of Clinical and Translational Neurology;2024-08-02

5. Binding of a Pyrene-Based Fluorescent Amyloid Ligand to Transthyretin: A Combined Crystallographic and Molecular Dynamics Study;The Journal of Physical Chemistry B;2023-07-21

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