1. Department of Medicine, Kuopio University Hospital, Kuopio, Finland;
2. Department of Medicine, University of Eastern Finland, Kuopio, Finland;
3. Department of Health, National Institute for Health and Welfare (THL), Helsinki, Finland;
4. Department of Medicine, North Karelia Central Hospital, Joensuu, Finland;
5. Heart Center, Turku University Hospital and University of Turku, Turku, Finland;
6. Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland