1. Department of Cardiothoracic Anaesthesiology, Copenhagen University Hospital, Copenhagen, Denmark;
2. Department of Cardiothoracic Surgery, Copenhagen University Hospital, Copenhagen, Denmark;
3. Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Copenhagen, Denmark;
4. Department of Surgery, University of Texas Health Medical School, Houston, TX, USA;
5. Center for Systems Biology, The School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland