Author:
Jahn Stephan W.,Jost Philipp J.
Abstract
SummaryProfiling of malignancies with next-generation sequencing (NGS) is now routine in clinical practice. While many cases of approved targeted therapies are straightforward based on well-characterized alterations, applying large NGS multigene panels to therapeutic use is frequently challenging. In this article, variant interpretation, therapy matching, and final treatment selection challenges are discussed.
Funder
Medical University of Graz
Publisher
Springer Science and Business Media LLC