Development of physical dependence on morphine in respect to time and dosage and quantification of the precipitated withdrawal syndrome in rats

Author:

Bl�sig J.,Herz A.,Reinhold K.,Zieglg�nsberger S.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology

Reference22 articles.

1. Buckett, W. R.: A new test for morphine-like physical dependence (addiction liability) in rats. Psychopharmacologia (Berl.) 6, 410?416 (1964)

2. Cheney, D. L., Goldstein, A.: Tolerance to opioid narcotics: time course and reversibility of physical dependence in mice Nature. (Lond.) 232, 471?478 (1971)

3. Cicero, T. J., Meyer, E. R.: Morphine pellet implantation in rats: quantitative assessment of tolerance and dependence. J. Pharmacol. exp. Ther. 184, 404?408 (1973)

4. Collier, H. O. J., Francis, D. L., Schneider, C.: Modification of morphine withdrawal by drugs interacting with neuronal mechanisms: some contradictions and their interpretations. Nature (Lond.) 237, 220?223 (1972)

5. Dewey, W. L., Harris, L. S.: Antinociceptive activity of the narcotic antagonist analgesics and antagonist activity of narcotic analgesics in rodents. J. Pharmacol. exp. Ther. 179, 652?659 (1971)

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